SPL RF Jul 2021

EN_01483637_0012

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caption

Molecular model of four G-protein-coupled receptors (GPCRs). From left to right the GPCRs are; rhodopsin, which is activated by absorbing light, T-cell receptor, which is activated by a major histocompatibility complex (MHC) class II molecule presenting an antigen (green), dopamine receptor, which is activated by dopamine (red), and gamma-aminobutyric acid receptor B (GABA-B receptor), being activated by the agonist drug baclofen. Activation of the receptors triggers a signalling cascade. In rhodopsin this is occurs when the GPCR's alpha subunit (light blue) activates phosphodiesterase 6, which breaks down cyclic guanosine monophosphate (cGMP) and leads to sodium channels closing. The other GPCRs activate the enzyme adenylyl cyclase, which produces cyclic adenosine monophosphate (cAMP). cAMP activates protein kinase C, which regulates numerous cell functions.

headline SPL RF Jul 2021

created date 2021-07-03

credit JUAN GAERTNER/Science Photo Library RF/East News

source Science Photo Library RF

byline JUAN GAERTNER

original transmission reference f0334518

weight 6,33MB

size 68cm x 51cm by 300dpi

keywords - Show

6, ACID, ADENOSINE, ADENYL, ADENYLYL, AGONIST, AMP, ANTIGEN, ARTWORK, ATP, BACLOFEN, BIOCHEMICAL, BIOCHEMISTRY, BIOLOGICAL, BIOLOGY, BOUND, C, CAMP, CAMP-DEPENDENT, CASCADE, CELL, CGMP, CLASS, COMMUNICATION, COMPLEX, COUPLED, CYCLASE, CYCLIC, DOPAMINE, DRUG, ENZYME, G, G-ALPHA, G-PROTEIN, G-PROTEIN-COUPLED, GABA, GABA-B, GAERTNER, GAMMA-AMINOBUTYRIC, GDP, GPCR, GTP, GUANINE, GUANOSINE, HISTOCOMPATIBILITY, II, ILLUSTRATION, JUAN, KINASE, LABEL, LABELED, LABELLED, LABELS, LIGHT, MAJOR, MEMBRANE, MESSENGER, MHC, MODEL, MOLECULAR, MOLECULE, MOLECULES, MONOPHOSPHATE, NEUROTRANSMITTER, NO-ONE, NOBODY, NUCLEOTIDE-BINDING, PATHWAY, PHOSPHODIESTERASE, PHOTORECEPTOR, PHOTOTRANSDUCTION, PROTEIN, PYROPHOSPHATE, RECEPTOR, RETINA, RETINAL, RHODOPSIN, SECOND, SIGNAL, SIGNALING, SIGNALLING, SUBUNIT, SWITCH, T-CELL, TEXT, TRANSDUCIN, TRANSDUCTION, TRIPHOSPHATE,